A ligand may only be compatible with one of the two receptor parts, while the other part remains incompatible with the ligand.
When an interval is dissonant, it sounds uglier, as though it needs to be “resolved” to something consonant.
The ligand tone will match the continuous rhythm of the receptor tones to represent a binding. Other ligand tones will be present, but will not attempt to bind to the receptor- they are playing separate, erratic rhythms.
The two tones are B-flat and E-flat. There are two examples of partially compatible bindings. First, we inserted a D between the tones- this is consonant with one of the two receptor notes (the B-flat, producing a major 3rd) and dissonant with the other (the E-flat, producing a minor 2nd).
This new note, a C-flat, is consonant with the E-flat (producing a major 3rd) but dissonant with the B-flat (producing a minor 2nd.) The consonant and dissonant intervals are the same in each partially compatible binding, but the compatible receptor has changed.
When multiple ligands bind to a cell’s receptors at the same time, they can bring about behavioral changes in the cell.
We chose to show this with a pair of bindings, represented by chords, evolving into a chord progression (then, a full piece of music!) If a ligand is incompatible or only partially compatible with a certain receptor pair, the cell’s behavior will be unaffected. Thus, a cell will change the nature of its receptors to match the ligand attempting to bind. This is represented by the receptor tones changing to become consonant with the original ligand tone.
Receptor 2 changes its two tones to become consonant with the original ligand tone which attempted to bind to it. Once multiple receptors have achieved full compatibility, a larger and more complex consonant chord is achieved, which gives way to an improvisation- something spontaneous, just as a cell may spontaneously be able to change its behavioral abilities.
Multiple Receptors and Ligands Binding at Once